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Observe Carefully (1)pentobarbital will minimize the level or impact of fentanyl transdermal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead on to a decrease in fentanyl plasma concentrations, not enough efficacy or, maybe, development of the wi